Table 3 Percentage of bone penetration of the main antibiotics used in AHOM
Antibiotic | Percentage of bone penetration | ||
|---|---|---|---|
Boselli 1999 [14] | Landrsdorfer 2009 [15] | Thabit 2019 [16] | |
BETA-LACTAMS | |||
Amoxicillin | 17–31% | 18–20% | 10% (amoxi-clavulanate) |
Clavulanic | – | 10–15% | – |
Ampicillin | 16% | 11–71% | – |
Sulbactam | – | 17–71% | – |
Piperacillin | 18–23% | 18–23% or 15% | 15% (piperacillin-tazobactam) |
Tazobactam | 22–26% | 22–26% | – |
Flucloxacillin | 8–15% | 5–15% | 65% |
Oxacillin | – | 11% | 21% |
CARBAPENEMS | |||
Ertapenem | – | 10–20% | 35% |
Meropenem | – | – | 50% |
CEPHALOSPORINS | |||
Ceftriaxone | – | 7–17% | – |
Cefazolin | 18% | 18% | 25% |
Cefepime | – | 46–76% | – |
Cefuroxime | 14–23% | – | – |
Cefotaxime | 8,8% | – | – |
Ceftazidime | 20–35% | 54% | 49% |
MACROLIDES | |||
Erythromycin | 28.5–39% | 18–28% | – |
Azithromycin | – | 250–630% | – |
GLYCOPEPTIDES | |||
Vancomycin | 60.8% | 5–67% | 20–40% |
Teicoplanin | 14–290% | 50–64% | – |
AMINOGLYCOSIDES | |||
Gentamicin | 14–55% | 16–33% | – |
Amikacin | 15–30% | – | – |
OTHERS | |||
Metronidazole | – | – | 50% |
Linezolida | – | 23–51% | 44% |
Daptomycin | – | 12–55% or 108% | 20% |
TMP-SMX | 11–60% | 15–50% | 25% |
Rifampicin | 17–41% | 20–25% | 40% |
Tigecyclinea | – | 35–195% or 47% | – |
Clindamycin | 98.3% | 21–45% | 26% |