Medications | Management | Drugs | Usual dosage |
---|---|---|---|
Immunoglobulins | Immunomodulatory: IVIG considered first-line therapy. | Single dose at 2 gm/kg based on ideal body weight | |
Glucocorticoids | Immunomodulatory: Glucocorticoids should be used as adjunctive therapy with severe disease or refractory disease. | 1–2 mg/kg/day, typically in two doses | |
0.15–0.4 mg/kg/day, PO or IV | |||
Prednisone [28] | 1–2 mg/kg/day, PO | ||
Monoclonal antibodies | Immunomodulatory: Lack of response to the treatment. | Starting dosing at 2–3 mg/kg q12h SC (total of 4–6 mg/kg/day, max: 100 mg/dose) | |
Tocilizumab [19] | Single IV dose (< 30 kg: 12 mg/kg IV; ≥ 30 kg: 8 mg/kg IV; max: 800 mg) | ||
5–10 mg/kg, 1 dose | |||
Anticoagulants | Anticoagulant thromboprophylaxis | 1Â mg/kg/day | |
Warfarin [19] | Therapeutic anticoagulation with warfarin | ||
Antiplatelet agents | Antiplatelet therapy | 3–5 mg/kg/day, max: 81 mg/day |