Fig. 3

Number of patients with causative mutation detected per gene per age group. Numbers on bars represent proportion of causative mutations in different age group: onset in the first 3 months of life (5 patients); 3–12 months (9 patients); aged 1–3 years (29 patients); aged 3–6 years (18 patients); aged 6–12 years (30 patients); and aged 12–18 years (9 patients)