Table 1 Definitions relating to the nephrotic syndrome in children
Term | Definition |
|---|---|
Nephrotic-range proteinuria | UPCR ≥ 200 mg/mmol (2 mg/mg) in a spot urine, or proteinuria ≥ 1000 mg/m2 per day in a 24 h urine sample corresponding to 3 + (300–1000 mg/ dL) or 4 + (≥ 1000 mg/dL) by urine dipstick |
Nephrotic syndrome | Nephrotic-range proteinuria and either hypoalbuminemia (serum albumin < 30 g/L) or edema when serum albumin is not available |
Complete remission | UPCR (based on first morning void or 24 h urine sample) ≤ 20 mg/mmol (0.2 mg/mg) or < 100 mg/m2 per day, respectively, or negative or trace dipstick on three or more consecutive days |
Partial remission | UPCR (based on first morning void or 24 h urine sample) > 20 but < 200 mg/mmol (> 0.2 mg/mg but < 2 mg/mg) and serum albumin ≥ 30 g/L |
No remission | No response was the presence of nephrotic range proteinuria, serum albumin of < 25 g/L, or edema |
SRNS | Lack of complete remission within 4 weeks of treatment with PDN at standard dose |
CNI-resistant SRNS | Absence of at least partial remission after 6 months of treatment with a CNI at adequate doses and/or levels. |